Detalhe da pesquisa
1.
Rapid characterization of adeno-associated virus (AAV) capsid proteins using microchip ZipChip CE-MS.
Anal Bioanal Chem
; 416(4): 1069-1084, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38102410
2.
A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency.
Int J Mol Sci
; 25(5)2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38474031
3.
Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins.
J Proteome Res
; 2023 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123456
4.
Exploring Charge-Detection Mass Spectrometry on Chromatographic Time Scales.
Anal Chem
; 95(40): 15118-15124, 2023 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37772750
5.
Automated Online-Sampling Multidimensional Liquid Chromatography with Feedback-Control Capability as a Framework for Real-Time Monitoring of mAb Critical Quality Attributes in Multiple Bioreactors.
Anal Chem
; 95(49): 18130-18138, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38015205
6.
Rapid Analysis of Biotherapeutics Using Protein A Chromatography Coupled to Orbitrap Mass Spectrometry.
Anal Chem
; 93(40): 13505-13512, 2021 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34585915
7.
A Native Mass Spectrometry-Based Assay for Rapid Assessment of the Empty:Full Capsid Ratio in Adeno-Associated Virus Gene Therapy Products.
Anal Chem
; 93(38): 12817-12821, 2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34519199
8.
Tracing production instability in a clonally derived CHO cell line using single-cell transcriptomics.
Biotechnol Bioeng
; 118(5): 2016-2030, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33586781
9.
Inline electrochemical reduction of NISTmAb for middle-up subunit liquid chromatography-mass spectrometry analysis.
Analyst
; 146(21): 6547-6555, 2021 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34585175
10.
Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells.
Int J Mol Sci
; 22(21)2021 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34768929
11.
Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level by Cation Exchange Chromatography and Capillary Electrophoresis Coupled to Mass Spectrometry.
Anal Chem
; 92(7): 5431-5438, 2020 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105056
12.
Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells.
Biotechnol Bioeng
; 117(8): 2489-2503, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32346860
13.
Inter-laboratory study of an optimised peptide mapping workflow using automated trypsin digestion for monitoring monoclonal antibody product quality attributes.
Anal Bioanal Chem
; 412(25): 6833-6848, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32710279
14.
Cracking Proteoform Complexity of Ovalbumin with Anion-Exchange Chromatography-High-Resolution Mass Spectrometry under Native Conditions.
J Proteome Res
; 18(10): 3689-3702, 2019 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31478673
15.
Salivary N-glycosylation as a biomarker of oral cancer: A pilot study.
Glycobiology
; 29(10): 726-734, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31245822
16.
Serum N-Glycosylation in Parkinson's Disease: A Novel Approach for Potential Alterations.
Molecules
; 24(12)2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31200590
17.
Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry.
Anal Chem
; 90(7): 4669-4676, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29494133
18.
Large-Scale Assessment of Extractables and Leachables in Single-Use Bags for Biomanufacturing.
Anal Chem
; 90(15): 9006-9015, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29943976
19.
Proteomics in biomanufacturing control: Protein dynamics of CHO-K1 cells and conditioned media during apoptosis and necrosis.
Biotechnol Bioeng
; 115(6): 1509-1520, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29427454
20.
Multiple reaction monitoring targeted LC-MS analysis of potential cell death marker proteins for increased bioprocess control.
Anal Bioanal Chem
; 410(13): 3197-3207, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29607450